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How to Use Tacrolimus Correctly

Follow the doctor’s recommendations and read the instructions for use listed on the packaging before using tacrolimus. Do not increase or decrease the dose, and do not use the drug for longer than the time recommended by your doctor. Tacrolimus in the form of intravenous fluids will be given by a doctor or medical officer under the supervision of a doctor at the hospital. Drug administration is carried out after organ transplantation. This Tacrolimus Compounding website can provide you with more information about the dose, content and function in the medical world.

Tacrolimus capsules can be taken before or after meals. Swallow the capsule whole with a glass of water and do not split or crush the capsule. It is recommended to take tacrolimus capsules at the same time every day for maximum benefits. For patients who forget to take tacrolimus capsules, it is recommended to take them immediately if the break with the next consumption schedule is not too close. If it is close, ignore it and do not double the dose.

Tacrolimus ointment should only be used on the skin, but should not be used on open wounds. Wash your hands before and after using this ointment. Apply a thin layer of ointment evenly on the inflamed area. Do not shower or swim immediately after using the ointment. If the ointment gets into your eyes, nostrils, or mouth, wash the area immediately with running water.

During treatment, you will be asked to do regular check-ups and undergo blood pressure checks so that the doctor can monitor your condition. Store tacrolimus capsules or ointment in a closed place in a cool temperature. Protect this medication from direct sunlight and keep it out of reach of children.

Interactions of Tacrolimus with Other Drugs

The use of tacrolimus with certain drugs can cause several drug interactions, such as:

  1. Increased blood levels of tacrolimus when used with antiviral drugs to treat hepatitis C and HIV infection, macrolide antibiotics, antifungals, ciclosporin, lansoprazole, amiodarone, cimetidine, or metoclopramide
  2. Increased risk of kidney and nervous system disorders when used with NSAIDs, aminoglycosides, vancomycin, cotrimoxazole, ganciclovir, or acyclovir
  3. Increased risk of developing hyperkalemia when used with potassium hemal diuretics, eg amiloride, triamterene, or spironolactone
  4. Decreased blood levels of tacrolimus when used with rifampicin, metamizole, phenytoin, carbamazepine, or isoniazid
  5. Decreased effectiveness of vaccines containing live attenuated viruses

In addition, there are several interaction effects that can occur if tacrolimus is taken together with certain foods, including:

  1. Increases blood levels of tacrolimus when taken with grapefruit
  2. Increases the risk of visual disturbances and neurological disorders if consumed with alcoholic beverages
  3. Interfere with the absorption of tacrolimus if consumed with high-fat foods

Tacrolimus Side Effects and Dangers

The side effects of using tacrolimus can vary, depending on the form of the drug. For tacrolimus ointment, side effects that can arise are the appearance of stinging, itching, burning, acne, or inflammation of the follicles (folliculitis). In addition, the use of tacrolimus capsules and injections has the risk of causing side effects such as shaking, headache, nausea, vomiting, stomach pain, or sleep disturbances.

Check with your doctor if the side effects above don’t go away or are getting worse. See your doctor immediately if you have an allergic reaction to the drug or a more serious side effect, such as:

  1. Fever, flu, runny nose, tired, pale skin, cold hands and feet
  2. Fainting, fast, irregular heartbeat, or chest pain
  3. Loss of balance, confusion, difficulty concentrating, movement disorders, seizures, or visual disturbances
  4. Hearing loss, such as ringing in the ears or deafness
  5. Heart failure which can be characterized by certain symptoms, such as difficulty breathing, swelling in the hands and feet, or unusual tiredness
  6. Impaired liver function that can be characterized by certain symptoms, such as jaundice, dark urine, severe and persistent nausea and vomiting, or severe abdominal pain.

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